pleckstrin homology domain-containing family A member 4; PH domain-containing family A member 4; phosphoinositol 3-phosphate-binding protein 1; PEPP-1 (PLEKHA4, PEPP1)

Function

• binds specifically to phosphatidylinositol-3-phosphate (Ptdins3P), but not to other phosphoinositides

Structure

contains 1 PH domain

Compartment

• cytoplasm (probable)
• peripheral membrane (probable)

Alternative splicing

named isoforms=2

Expression

• highly expressed in melanoma
• detected at low levels in heart, skeletal muscle, kidney, liver & small intestine

More general terms

• pleckstrin homology domain containing family A (PLEKHA)

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57664
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57664
• OMIM: https://mirror.omim.org/entry/607769
• UniProt: http://www.uniprot.org/uniprot/Q9H4M7.html