solute carrier family 35 member B2 (SLC35B2, adenosine 3'-phospho 5'-phosphosulfate transporter 1, PAPS transporter 1, MAPK-activating protein PM15, NF-kappa-B-activating protein 48, PAPST1, PSEC0149)

Function

• mediates transport of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), from cytosol into Golgi
• may indirectly participate in activation of NF-kappa-B & MAPK pathways

Kinetic parameters: KM=0.8 uM for PAPS

Structure

• belongs to the nucleotide-sugar transporter family SLC35B subfamily

Compartment

Golgi membrane

Alternative splicing

named isoforms=3

Expression

• highly expressed in the placenta, pancreas, mammary gland & skeletal muscle
• weakly or not expressed in colon, heart & prostate

More general terms

• solute carrier family 35
• transmembrane 9 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3477
• OMIM: https://mirror.omim.org/entry/610788
• UniProt: http://www.uniprot.org/uniprot/Q8TB61.html