LAG1 longevity assurance homolog 1; longevity assurance gene 1 protein homolog 1; protein UOG-1 (LASS1, CERS1, LAG1, UOG1)

Function

• may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity
• when overexpressed in cells, is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide)

Structure

• contains 1 TLC (TRAM/LAG1/CLN8) domain

Compartment

• endoplasmic reticulum (ER) membrane
• isoform 1:
  • ER membrane, Golgi membrane
  • may recycle from the Golgi to ER

Alternative splicing

named isoforms=2

Genetics

• produced from a bicistronic gene which also produces GDF1 from a non-overlapping reading frame

More general terms

• transmembrane 6 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10715
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10715
• OMIM: https://mirror.omim.org/entry/606919
• UniProt: http://www.uniprot.org/uniprot/P27544.html