protein-S-isoprenylcysteine O-methyltransferase; isoprenylcysteine carboxylmethyltransferase; prenylated protein carboxyl methyltransferase; PPMT; prenylcysteine carboxyl methyltransferase; pcCMT (ICMT, PCCMT)

Function

• catalyzes post-translational methylation of isoprenylated C-terminal Cys

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl- L-cysteine methyl ester

Cofactor: divalent cations, probably Zn+2 (putative)

Structure

• belongs to the isoprenylcysteine O-methyltransferase family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein

Expression

• ubiquitously expressed
• expressed at higher levels in the cerebellum & putamen than in other brain regions
• abundant expression seen in Purkinje cells & pontine neurons

More general terms

• O-methyl transferase
• transmembrane 4 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23463
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23463
• OMIM: https://mirror.omim.org/entry/605851
• UniProt: http://www.uniprot.org/uniprot/O60725.html