ectonucleoside triphosphate diphosphohydrolase 2; NTPDase 2; CD39 antigen-like 1; ecto-ATP diphosphohydrolase 2; ecto-ATPDase 2; ecto-ATPase 2 (ENTPD2, CD39L1)

Function

• in the nervous system, could hydrolyze ATP & other nucleotides to regulate purinergic neurotransmission
• hydrolyzes ADP only to a marginal extent
• the order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP

Cofactor: Ca+2, Mg+2

Structure

belongs to the GDA1/CD39 NTPase family

Compartment

membrane (potential)

Alternative splicing

named isoforms=2; long, short

Expression

• brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate & pancreas
• no expression in adult thymus, spleen, lung, liver & peripheral blood leukocytes

More general terms

• CD39 like protein
• transmembrane 2 protein

Additional terms

• CD39; ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; ecto-ATP diphosphohydrolase; ATPDase; lymphoid cell activation antigen; ecto-apyrase (ENTPD1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=954
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:954
• OMIM: https://mirror.omim.org/entry/602012
• UniProt: http://www.uniprot.org/uniprot/Q9Y5L3.html