Na+/K+ ATPase-alpha 4 (Na+ pump subunit alpha-4, Na+/K+ ATPase alpha-4 subunit, ATP1A4, ATP1AL2)

Function

• catalytic component of the active enzyme
• catalyzes the hydrolysis of ATP coupled with exchange of Na+ & K+ ions across the plasma membrane
• action creates the electrochemical gradient of Na+ & K+ ions, providing energy for active transport of various nutrients

Structure

• belongs to the cation transport ATPase (P-type) family, type IIC subfamily

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• highly expressed in testis
• found in very low levels in skeletal muscle

More general terms

• Na+/K+ ATPase-alpha

Additional terms

• Na+/K+ ATPase

Database

• OMIM: https://mirror.omim.org/entry/607321
• UniProt: http://www.uniprot.org/uniprot/Q13733.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=480