chemokine-like receptor 1; G-protein coupled receptor chemR23; G-protein coupled receptor DEZ (CMKLR1, CHEMR23, DEZ)

Function

• orphan receptor
• could be a chemotactic peptide receptor
• may have a function in bone metabolism

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2; A, B

Expression

• expressed during bone development in developing osseous & cartilagenous tissue
• also found in adult parathyroid

Pathology

• acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR & SIVSM62A), as well as a primary HIV-1 strain (92UG024-2)

More general terms

• chemokine receptor (chemoattractant receptor)
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1240
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1240
• OMIM: https://mirror.omim.org/entry/602351
• UniProt: http://www.uniprot.org/uniprot/Q99788.html