signal transduction protein CBL-C (SH3-binding protein CBL-C, CBL-3, RING finger protein 57, CBLC, CBL3, RNF57)

Function

• regulator of EGFR mediated signal transduction
• interacts with a restricted range of SH3 domain proteins
• RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme
• phosphorylated on tyrosines by EGFR
• one functional calcium-binding site

Structure

• contains 1 CBL N-terminal domain
  • contains 2 EF-hand-like domains
  • contains 1 RING-type zinc finger
  • contains 1 SH2 domain
• N-terminus consists of
  • phosphotyrosine binding domain (PTB domain):
    • 3 different subdomains:
    • a 4-helix bundle (4H)
    • a Ca+2-binding EF hand
    • a divergent SH2 domain
  • a short linker region
  • RING-type zinc finger

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• ring finger protein

Database

• OMIM: https://mirror.omim.org/entry/608453
• UniProt: http://www.uniprot.org/uniprot/Q9ULV8.html