zinc finger protein 518 (ZNF518, ZNF518A)
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Function
- transcriptional regulation
- role in timing of menopause
* protein-truncating variants in ZNF518A are associated with earlier age at menopause (by 5.61 years) & later age at menarche (by 0.56 years)[2]
Structure
- belongs to the krueppel C2H2-type zinc-finger protein family
- contains 5 C2H2-type zinc fingers
Compartment
Alternative splicing
named isoforms=2
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q6AHZ1.html
- ↑ 2.0 2.1 Ledford H Why some women enter menopause early - and how that could affect their cancer risk. Nature. 11 September 2024 PMID: https://www.ncbi.nlm.nih.gov/pubmed/39261698 https://www.nature.com/articles/d41586-024-02905-5
Stankovic S, Shekari S, Huang QQ et al Genetic links between ovarian ageing, cancer risk and de novo mutation rates. Nature. 2024 Sep 11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39261734 https://www.nature.com/articles/s41586-024-07931-x