zinc finger protein 278; POZ-, AT hook-, & zinc finger-containing protein 1; BTB/POZ domain zinc finger transcription factor; protein kinase A RI subunit alpha-associated protein; zinc finger & BTB domain-containing protein 19; zinc finger sarcoma gene protein (PATZ1, PATZ, RIAZ, ZBTB19, ZNF278, ZSG)

Function

• transcriptional repressor

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 1 A.T hook DNA-binding domain
• contains 1 BTB/POZ domain
• contains 7 C2H2-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=4

Expression

ubiquitous

Pathology

• chromosomal translocation t(1;22)(p36.1;q12) involving ZNF278 with EWSR1 is associated with small round cell sarcoma

More general terms

• C2H2 type zinc finger protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23598
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23598
• OMIM: https://mirror.omim.org/entry/605165
• UniProt: http://www.uniprot.org/uniprot/Q9HBE1.html