zinc finger protein 81; HFZ20 (ZNF81)

Function

• may be involved in transcriptional regulation

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 12 C2H2-type Zn+2 fingers
• contains 1 KRAB domain

Compartment

nucleus (probable)

Pathology

• defects in ZNF81 are the cause of non-syndromic mental retardation X-linked type 45
• chromosomal translocation t(X;9)(p11.23;q34.3) involving ZNF81 found in a patient with severe mental retardation

More general terms

• nuclear protein
• C2H2 type zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3473
• OMIM: https://mirror.omim.org/entry/300498
• OMIM: https://mirror.omim.org/entry/314998
• UniProt: http://www.uniprot.org/uniprot/P51508.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7635