apolipoprotein C1; apo-C1B (APOC1, APOC1B)

Function

• appears to modulate the interaction of APOE with beta- migrating VLDL & inhibit binding of beta-VLDL to the LDL receptor-related protein (LRP)
• binds free fatty acids & reduces their intracellular esterification
• activates LCAT & may activate certain forms of lipoprotein lipase

Structure

belongs to the apolipoprotein C1 family

Compartment

secreted

Expression

• expression mainly in liver
• lesser expression in intestine
• secreted into plasma

Comparative biology

• apo C1 is present in acidic (APOC1A) & basic (APOC1B) forms in P paniscus, P abelii & P troglodytes & perhaps also in baboons & macaques
• in humans, the acidic form has become a pseudogene

Notes

• apo C1 makes up about 10% of the protein of the VLDL & 2% of that of HDL

More general terms

• apolipoprotein C

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=341
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:341
• OMIM: https://mirror.omim.org/entry/107710
• UniProt: http://www.uniprot.org/uniprot/P02654.html