ATP-dependent DNA helicase PIF1 (PIF1/RRM3 DNA helicase-like protein, PIF1, C15orf20)

Function

• DNA-dependent ATPase & DNA helicase
• inhibits telomerase activity by unwinding DNA/RNA duplex formed by telomerase RNA & telomeric DNA in a 5' to 3' polarity
• negatively regulates telomere length, inhibition requires its ATPase activity
• interacts with telomerase

Structure

belongs to the helicase family, RAD3/XPD subfamily

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• weak ubiquitous expression
• tightly cell cycle regulated, expressed in late S/G2 phase

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H611.html