ATP-dependent DNA helicase Q5; DNA helicase, recQ-like type 5; recQ5; recQ protein-like 5 (RECQL5. RECQ5)

Function

• helicase
• role in DNA metabolism
• interacts with TOP3A & TOP3B

Structure

• belongs to the helicase family, recQ subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

• isoform alpha: cytoplasm
• isoform beta: nucleus, nucleoplasm
• isoform gamma: cytoplasm

Alternative splicing

named isoforms=3; alpha, beta, gamma

Expression

ubiquitous

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9400
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9400
• OMIM: https://mirror.omim.org/entry/603781
• UniProt: http://www.uniprot.org/uniprot/O94762.html