DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1 (TOP3B, TOP3B1)

Function

• possesses negatively supercoiled DNA relaxing activity
• ATP-independent breakage of single-stranded DNA, followed by passage & rejoining

Structure

• belongs to the prokaryotic type I/III topoisomerase family
• contains 1 Toprim domain

Alternative splicing

named isoforms=3

Expression

• isoform 1 is found in testis, heart & skeletal muscle
• a 4 kb transcript which probably represents isoform 2 is found in thymus, kidney & pancreas

More general terms

• topoisomerase-3

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8940
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8940
• OMIM: https://mirror.omim.org/entry/603582
• UniProt: http://www.uniprot.org/uniprot/O95985.html