ATP-dependent DNA helicase Q1; DNA-dependent ATPase Q1; recQ protein-like 1; DNA helicase, recQ-like type 1; recQ1 (RECQL, RECQ1, RECQL1)

Function

• DNA helicase
• role in repair of DNA damaged by ultraviolet light &/or other mutagens (putative)
• Mg+2-dependent ATP-dependent DNA-helicase activity that unwinds single-stranded DNA & double-stranded DNA in a 3'-5' direction
• interacts with EXO1 & MLH1

Structure

• belongs to the helicase family, recQ subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

nucleus

Expression

• high expression in heart, lung, skeletal muscle & kidney, low expression in brain

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5965
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5965
• OMIM: https://mirror.omim.org/entry/600537
• UniProt: http://www.uniprot.org/uniprot/P46063.html