beta-defensin 4; beta-defensin 104; BD-4; DEFB-4; hBD-4; defensin, beta 104 (DEFB104A, DEFB104, DEFB4, DEFB104B)

Function

• antimicrobial activity
• synergistic effects with lysozyme & DEFB103

Structure

belongs to the beta-defensin family

Compartment

secreted

Expression

• expressed in testis > gastric antrum > uterus, neutrophils, thyroid gland, lung, & kidney
• no detectable expression in other tissues tested
• antimicrobial activity is decreased when the Na+/Cl- concentration is increased

More general terms

• beta defensin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=140596
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=503618
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:140596
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:503618
• UniProt: http://www.uniprot.org/uniprot/Q8WTQ1.html