general transcription factor IIH subunit 2; basic transcription factor 2 44 kD subunit; BTF2 p44; general transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunit (GTF2H2 BTF2P44)

Function

• component of the core-TFIIH basal transcription factor
• role in nucleotide excision repair of DNA
• when complexed to CAK, role in RNA transcription by RNA polymerase 2
• the N-terminus interacts with & regulates XPD
• an intact C-terminus is required for a successful escape of RNA polymerase 2 from the promoter
• interacts with XPB, XPD, GTF2H1 & GTF2H3

Structure

• belongs to the GTF2H2 family
• contains 1 VWFA domain

Compartment

nucleus

Alternative splicing

• named isoforms=1
• a number of isoforms may be produced
• isoforms may be also produced by incomplete gene duplication

Expression

• widely expressed
• higher expression in skeletal muscle

More general terms

• transcription factor IIH subunit
• zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2966
• OMIM: https://mirror.omim.org/entry/601748
• UniProt: http://www.uniprot.org/uniprot/Q13888.html