F-box-like/WD repeat-containing protein TBL1Y; transducin beta-like protein 1Y; transducin-beta-like protein 1, Y-linked (TBL1Y, TBL1)

Function

• F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units
• role in transcription activation mediated by nuclear receptors
• probable component of the N-cor repressor complex & some E3 ubiquitin ligase complex (putative)

Structure

• the F-box-like domain is related to the F-box domain, & apparently displays the same function as a component of ubiquitin E3 ligase complexes (putative)
• belongs to the WD repeat EBI family
• contains 1 F-box-like domain
• contains 1 LisH domain
• contains 8 WD repeats

Compartment

nucleus (putative)

Expression

fetal brain & prostate

More general terms

• F-box & WD-repeat protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=90665
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:90665
• OMIM: https://mirror.omim.org/entry/400033
• UniProt: http://www.uniprot.org/uniprot/Q9BQ87.html