hydroxyacylglutathione hydrolase, mitochondrial; glyoxalase II; Glx II (HAGH, GLO2, HAGH1)

Function

• glyoxal pathway
• thiolesterase catalyzing hydrolysis of S-D-lactoyl- glutathione to form glutathione & D-lactic acid
• monomer

S-(2-hydroxyacyl)glutathione + H2O
            <-->
glutathione + 2-hydroxy carboxylate.

Cofactor:

• binds 2 Zn+2

Structure

• monomer
• belongs to the metallo-beta-lactamase superfamily Glyoxalase II family

Compartment

• isoform 1: mitochondrial matrix
• isoform 2: cytoplasm

Alternative splicing

• alternative initiation
• named isoforms=2
• produced by alternative splicing
• also produced by alternative initiation at Met-49 of isoform 1

Expression

• expressed in liver & kidney

Genetics

• only one single gene encoding glyoxalase II has been identified in vertebrates
• in yeast & higher plants, separate genes encode the cytosolic & mitochondrial forms of glyoxalase II

More general terms

• thiol esterase or thioesterase

Additional terms

• lactoylglutathione lyase; methylglyoxalase; aldoketomutase; glyoxalase I; Glx I; ketone-aldehyde mutase; S-D-lactoylglutathione methylglyoxal lyase (GLO1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3029
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3029
• OMIM: https://mirror.omim.org/entry/138760
• UniProt: http://www.uniprot.org/uniprot/Q16775.html