lactoylglutathione lyase; methylglyoxalase; aldoketomutase; glyoxalase I; Glx I; ketone-aldehyde mutase; S-D-lactoylglutathione methylglyoxal lyase (GLO1)

Function

• catalyzes conversion of hemimercaptal, formed from methylglyoxal & glutathione, to S-lactoylglutathione
• secondary metabolite metabolism; methylglyoxal degradation; D-lactate from methylglyoxal: step 1/2

Cofactor: binds 1 Zn+2 per subunit

Structure

• homodimer
• belongs to the glyoxalase I family

Polymorphism

• 3 separable isoforms which originate from 2 alleles in the genome
• these correspond to two homodimers & one heterodimer composed of two subunits showing different electrophoretic properties

More general terms

• lyase

Additional terms

• hydroxyacylglutathione hydrolase, mitochondrial; glyoxalase II; Glx II (HAGH, GLO2, HAGH1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q04760.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2739
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2739
• OMIM: https://mirror.omim.org/entry/138750