tachykinin-4; preprotachykinin-C; PPT-C [contains: endokinin-A (EKA); endokinin-A/B (EKA/B); endokinin-C (EKC)] (TAC4)

Function

• tachykinins
• endokinin-A induces thermal hyperalgesia & pain-related behavior such as scratching following intrathecal administration in rats
• these effects are suppressed by treatment with endokinin-C
• endokinin-A/B reduces arterial blood pressure & increases sperm motility

Structure

belongs to the tachykinin family

Compartment

secreted (probable)

Alternative splicing

named isoforms=7

Expression

• expressed at low levels in the uterus of both pregnant & non-pregnant women
• isoform 1 is found only in the adrenal gland & fetal liver
• isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland & testis.
• isoform 3 & isoform 4 are expressed predominantly in adrenal gland & placenta
• isoform 6 is widely expressed with high levels in skin

More general terms

• tachykinin (neurokinin)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2550
• OMIM: https://mirror.omim.org/entry/607833
• UniProt: http://www.uniprot.org/uniprot/Q86UU9.html