ubiquitin carboxyl-terminal hydrolase 36; deubiquitinating enzyme 36; ubiquitin thiolesterase 36; ubiquitin-specific-processing protease 36 (USP36, KIAA1453)

Function

• may be required for maintaining multiple types of adult stem cells
• may function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thus preventing histone H3 Lys-4 trimethylation
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• interacts with PAF1 (putative)

Structure

belongs to the peptidase C19 family

Compartment

nucleus, nucleolus

Alternative splicing

named isoforms=2

Expression

broadly expressed

More general terms

• ubiquitin C-terminal hydrolase
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57602
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57602
• OMIM: https://mirror.omim.org/entry/612543
• UniProt: http://www.uniprot.org/uniprot/Q9P275.html