ubiquitin carboxyl-terminal hydrolase 24; deubiquitinating enzyme 24; ubiquitin thiolesterase 24; ubiquitin-specific-processing protease 24 (USP24, KIAA1057)

Function

• role in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (putative)
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the peptidase C19 family
• contains 1 UBA domain

More general terms

• ubiquitin C-terminal hydrolase
• phosphoprotein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23358
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23358
• OMIM: https://mirror.omim.org/entry/610569
• UniProt: http://www.uniprot.org/uniprot/Q9UPU5.html