ubiquitin carboxyl-terminal hydrolase 15; deubiquitinating enzyme 15; ubiquitin thiolesterase 15; ubiquitin-specific-processing protease 15; Unph-2; Unph4 (USP15, KIAA0529)

Function

• protease that degrades Lys-48-linked polyubiquitin chains
• protects target proteins against proteasomal degradation
• protects APC & human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• phosphorylation protects against ubiquitination & subsequent degradation by the proteasome
• ubiquitinated, leading to degradation by the proteasome
• identified in a complex with the COP9 signalosome complex

Structure

• belongs to the peptidase C19 family
• contains 1 DUSP domain

Alternative splicing

named isoforms=3

Expression

• expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, & ovary
• little or no expression in other tissues

Pathology

• protects human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway

More general terms

• ubiquitin C-terminal hydrolase
• phosphoprotein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Component of

• COP9 signalosome complex (CSN complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9958
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9958
• OMIM: https://mirror.omim.org/entry/604731
• UniProt: http://www.uniprot.org/uniprot/Q9Y4E8.html