P2Y4 purinoceptor; G-protein coupled pyrimidinergic receptor P2Y4; P2Y purinoceptor 4; P2Y4; uridine nucleotide receptor; UNR; P2P (P2RY4, NRU)

Function

• receptor for UTP & UDP
• coupled to G-proteins that activate phosphatidylinositol-Ca+2 second messenger system
• not activated by ATP or ADP
• phosphorylation of Ser-333 & Ser-334 is a key step in agonist-dependent desensitization & loss of surface P2RY4
• phosphorylation does not involve PKC, nor other Ca+2 activated kinases

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

pancreas

More general terms

• P2Y purinoceptor or P2Y purinergic receptor
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5030
• OMIM: https://mirror.omim.org/entry/300038
• UniProt: http://www.uniprot.org/uniprot/P51582.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5030