opioid growth factor receptor (opioid growth factor receptor, OGFr, 7-60 protein)

Function

• receptor for opioid growth factor (OGF), also known as Met-enkephalin
• seems to be involved in growth regulation
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the opioid growth factor receptor family

Compartment

• cytoplasm, nucleus (putative)
• the OGF/OGFR complex is probably translocated to the nucleus

Alternative splicing

named isoforms=2

Expression

• highly expressed in the heart & liver > skeletal muscle & kidney > brain & pancreas
• expressed in fetal tissues including liver & kidney

More general terms

• endorphin receptor or opioid receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1105
• OMIM: https://mirror.omim.org/entry/606459
• UniProt: http://www.uniprot.org/uniprot/Q9NZT2.html