prostaglandin E2 receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2-R; prostanoid EP3 receptor (PTGER3)

Function

• receptor for prostaglandin E2 (PGE2)
• may be involved in
  • inhibition of gastric acid secretion
  • modulation of neurotransmitter release in central & peripheral neurons
  • inhibition of Na+ & water reabsorption in renal tubules
  • contraction in uterine smooth muscle
• activity can couple to both the inhibition of a denylate cyclase mediated by Gi proteins, & to an elevation of intracellular Ca+2
• various isoforms have identical ligand binding properties but can interact with different second messenger systems (putative)

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Alternative splicing

named isoforms=7 Additional isoforms seem to exist

• EP3A (EP3-I, EP3a1, EP3a2, EP(3-Ic))
• EP3C (EP3-II, EP3D)
• EP3B (EP3-III, EP3E)
• EP3D (EP3-IV, EP3F)
• EP3E
• EP3F
• EP3G

Expression

• expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery & pulmonary vessels

More general terms

• prostaglandin-E [PGE] receptor
• glycoprotein

More specific terms

• prostaglandin-E2 receptor, EP3a subtype
• prostaglandin-E2 receptor, EP3b subtype
• prostaglandin-E2 receptor, EP3c subtype
• prostaglandin-E2 receptor, EP3d subtype
• prostaglandin-E2 receptor, EP3e subtype
• prostaglandin-E2 receptor, EP3f subtype

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5733
• OMIM: https://mirror.omim.org/entry/176806
• UniProt: http://www.uniprot.org/uniprot/P43115.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5733