prostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor; PGE receptor, EP1 subtype (PTGER1)

Function

• receptor for prostaglandin E2 (PGE2)
• activity is mediated by G(q) proteins which activate a phosphatidylinositol-Ca+2 second messenger system
• may play a role as an important modulator of renal function
• implicated the smooth muscle contractile response to PGE2 in various tissues
• phosphorylated (putative)

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• abundant in kidney
• lower level expression in lung, skeletal muscle & spleen, lowest expression in testis
• not detected in liver brain & heart

More general terms

• prostaglandin-E [PGE] receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5731
• OMIM: https://mirror.omim.org/entry/176802
• UniProt: http://www.uniprot.org/uniprot/P34995.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5731