melatonin receptor type 1A; mel1a melatonin receptor; mel-1A-R (MTNR1A)

Function

• high affinity receptor for melatonin
• likely to mediate reproductive & circadian actions of melatonin
• activity is mediated by pertussis toxin sensitive Gi proteins

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• expressed in hypophyseal pars tuberalis & hypothalamic suprachiasmatic nuclei (SCN)
• expressed in hippocampus

More general terms

• melatonin receptor
• glycoprotein

Additional terms

• melatonin

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4543
• OMIM: https://mirror.omim.org/entry/600665
• UniProt: http://www.uniprot.org/uniprot/P48039.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4543