cannabinoid receptor 2; CB-2; CB2; CX5 (CNR2)
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Function
- role in cannabinoid-induced CNS effects through G-protein mediated inhibition of adenylate cyclase
- receptor for anandamide
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
Expression
- not found in brain
- found in spleen
- found predominantly on immune system cells
Pathology
- cannabinoids may slow progression of atherosclerosis through effects on CB2 receptors[2]
More general terms
References
- ↑ Munro et al Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7689702
- ↑ 2.0 2.1 Journal Watch 25(12):98, 2005 Steffens S, Veillard NR, Arnaud C, Pelli G, Burger F, Staub C, Karsak M, Zimmer A, Frossard JL, Mach F. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature. 2005 Apr 7;434(7034):782-6. Erratum in: Nature. 2005 May 26;435(7041):528. Karsak, Meliha [added]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15815632
Roth MD. Pharmacology: marijuana and your heart. Nature. 2005 Apr 7;434(7034):708-9. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15815611 - ↑ UniProt http://www.uniprot.org/uniprot/P34972.html