keratin, type I cytoskeletal 26 (cytokeratin-26, keratin-26, type 1 inner root sheath-specific keratin-K25irs2, keratin 25B, KRT26, KRT25B)
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Introduction
heterotetramer of 2 type 1 & two type 2 keratins
Structure
belongs to the intermediate filament family
Expression
- strongly expressed in skin & scalp, & weak expression observed in thymus & tongue
- in the hair follicle, expression is restricted to the mid- to upper inner root sheath cuticle
- present slightly above the apex of the dermal papilla (at protein level)
Notes
- 2 types of cytoskeletal & microfibrillar keratin: 1 (acidic; 40-55 kD) 2 (neutral to basic; 56-70 kD)