keratin, type 1 cytoskeletal 15; cytokeratin-15; CK-15; keratin-15; K15 (KRT15 KRTB)

Structure

• type 1 cytokeratin
• heterotetramer of 2 type 1 & tw2 type 2 keratins
• belongs to the intermediate filament family

Expression

• expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis & nail
• also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level)
• expressed homogeneously in all cell layers of the esophagus & exo-cervix, but detected in the basal cell layer only of oral mucosa, skin & in the basal plus the next two layers of the suprabasal epithelium of the palate

More general terms

• cytokeratin, epithelial keratins or soft alpha-keratins

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3866
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3866
• OMIM: https://mirror.omim.org/entry/148030
• UniProt: http://www.uniprot.org/uniprot/P19012.html