keratin, type 1 cytoskeletal 13; cytokeratin-13; CK-13; keratin-13; K13 (KRT13)

Function

• keratin-13 is generally associated with keratin-4

Structure

• O-glycosylated; glycans consist of single N-acetylglucosamine residues
• heterotetramer of 2 type 1 & 2 type 2 keratins
• belongs to the intermediate filament family

Alternative splicing

named isoforms=2

Expression

• expressed in some epidermal sweat gland ducts (at protein level) & in exocervix, esophagus & placenta
• suprabasal cells express keratins-4 & keratin-13

Pathology

• defects in KRT13 are a cause of white sponge nevus of Cannon

More general terms

• cytokeratin, epithelial keratins or soft alpha-keratins
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3860
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3860
• OMIM: https://mirror.omim.org/entry/148065
• OMIM: https://mirror.omim.org/entry/193900
• UniProt: http://www.uniprot.org/uniprot/P13646.html