white sponge nevus of Cannon
Jump to navigation
Jump to search
Epidemiology
- rare
- familial
Pathology
- benign & permanent lesion
- predominantly affects non-cornified stratified squamous epithelia
- epithelial thickening, parakeratosis, & vacuolization of the suprabasal layer of oral epithelial keratinocytes
Genetics
- autosomal dominant
- associated with defects in KRT4
Clinical manifestations
- onset in adolescence or early adulthood
- painless, soft, white, & spongy plaques in the oral mucosa
- less frequently the mucous membranes of the nose, esophagus, genitalia & rectum are involved
More general terms
Additional terms
References
- ↑ Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 204
- ↑ OMIM https://mirror.omim.org/entry/193900
- ↑ Songu M, Adibelli H, Diniz G. White sponge nevus: clinical suspicion and diagnosis. Pediatr Dermatol. 2012 Jul-Aug;29(4):495-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22352924