keratin, type 1 cytoskeletal 12; cytokeratin-12; CK-12; keratin-12; K12 (KRT12)

Function

• may play a unique role in maintaining the normal corneal epithelial function
• together with KRT3, essential for maintenance of corneal epithelium integrity (putative)
• keratin-3 associates with keratin-12

Structure

• type 1 keratin
• heterotetramer of 2 type 1 & 2 type 2 keratins
• belongs to the intermediate filament family

Expression

cornea specific

Pathology

• defects in KRT12 are a cause of juvenile epithelial corneal dystrophy of Meesmann

More general terms

• cytokeratin, epithelial keratins or soft alpha-keratins

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3859
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3859
• OMIM: https://mirror.omim.org/entry/122100
• OMIM: https://mirror.omim.org/entry/601687
• UniProt: http://www.uniprot.org/uniprot/Q99456.html