DNA ligase-1; polydeoxyribonucleotide synthase [ATP] 1 (LIG1)

Function

• seals nicks in double-stranded DNA, during
  • DNA replication
  • DNA recombination
  • DNA repair

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m)
                  <-->
AMP + diphosphate + (deoxyribonucleotide)(n+m)

Structure

belongs to the ATP-dependent DNA ligase family

Compartment

nucleus

Pathology

• defects in LIG1 seem to cause immunodeficiencies & cellular hypersensitivity to DNA-damaging agents

More general terms

• ATP-dependent DNA ligase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P18858.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3978
• OMIM: https://mirror.omim.org/entry/126391