hydroxyindole O-methyltransferase; HIOMT; acetylserotonin O-methyltransferase; ASMT (ASMT)

Function

• aromatic compound metabolism; melatonin biosynthesis
• melatonin from serotonin: step 1/2

S-adenosyl-L-methionine + N-acetylserotonin
              <-->
S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine

Structure

• includes part of a LINE-1 element
• belongs to the methyltransferase superfamily

Alternative splicing

named isoforms=3

Expression

• most abundant in pineal gland, less in retina & brain
• not expressed in pigment epithelium

Genetics

• gene encoding HIOMT is located in the pseudoautosomal region 1 (PAR1) of X & Y chromosomes

More general terms

• O-methyl transferase

Database

• UniProt: http://www.uniprot.org/uniprot/P46597.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=438
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:438
• OMIM: https://mirror.omim.org/entry/300015
• OMIM: https://mirror.omim.org/entry/402500