N(2),N(2)-dimethylguanosine tRNA methyltransferase; tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase (TRMT1)

Function

• dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups

S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N(2)-methylguanine

Structure

contains 1 C3H1-type Zn+2 finger

Alternative splicing

named isoforms=2

More general terms

• N-methyltransferase
• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55621
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55621
• OMIM: https://mirror.omim.org/entry/611669
• UniProt: http://www.uniprot.org/uniprot/Q9NXH9.html