glycine N-methyltransferase (GNMT)

Function

• catalyzes methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with concomitant production of S-adenosylhomocysteine (AdoHcy)
• possible role in regulation of tissue concentration of AdoMet & of metabolism of methionine

S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine

Structure

• homotetramer
• belongs to the glycine N-methyltransferase family

Compartment

cytoplasm

Expression

abundant in liver

Pathology

• defects in GNMT are the cause of glycine N-methyltransferase deficiency

More general terms

• N-methyltransferase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27232
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27232
• OMIM: https://mirror.omim.org/entry/606628
• OMIM: https://mirror.omim.org/entry/606664
• UniProt: http://www.uniprot.org/uniprot/Q14749.html