guanidinoacetate N-methyltransferase (GAMT)

Function

• amine & polyamine biosynthesis; creatine biosynthesis creatine from L-arginine & glycine: step 2/2

S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine

Structure

• monomer (putative)
• belongs to the RMT2 methyltransferase family

Expression

expressed in liver

Pathology

• defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency

More general terms

• N-methyltransferase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2593
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2593
• OMIM: https://mirror.omim.org/entry/601240
• OMIM: https://mirror.omim.org/entry/612736
• UniProt: http://www.uniprot.org/uniprot/Q14353.html