microsomal glutathione S-transferase 2 (microsomal GST- 2, microsomal GST-II, MGST2, GST2)

Function

• can catalyze the production of LTC4 from LTA4 & reduced glutathione
• can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione

RX + glutathione = HX + R-S-glutathione

Structure

• homotrimer
• belongs to the MAPEG family

Compartment

membrane (potential)

Expression

• liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, & fetal spleen
• very low expression in lung, brain, placenta & bone marrow

More general terms

• microsomal glutathione S-transferase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4258
• OMIM: https://mirror.omim.org/entry/601733
• UniProt: http://www.uniprot.org/uniprot/Q99735.html