glucosamine 6-phosphate N-acetyltransferase; phosphoglucosamine acetylase; phosphoglucosamine transacetylase (GNPNAT1, GNA1)

Function

• nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2

acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate

Kinetic parameters:

• KM=26 uM for acetyl-coenzyme A
• KM=97 uM for glucosamine-6-phosphate

Structure

• homodimer
• belongs to the acetyltransferase family, GNA1 subfamily
• contains 1 N-acetyltransferase domain

Compartment

• Golgi membrane
• peripheral membrane protein
• endosome membrane

Laboratory

• glucosamine N-acetyltransferase in fibroblasts*
• glucosamine N-acetyltransferase in leukocytes*

* Loincs may be inappropriately named

* Lab test may measure glucosamine 6-phosphate N-acetyltransferase as no UniProt entry for glucosamine N-acetyltransferase exists

More general terms

• acetyltransferase
• membrane protein

Additional terms

• CDC42 homolog; cell division control protein 42 homolog; G25K GTP-binding protein (CDC42)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64841
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64841
• UniProt: http://www.uniprot.org/uniprot/Q96EK6.html