type 2 inositol-3,4-bisphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type 2 (INPP4B)

Function

• catalyzes hydrolysis of the 4-position phosphate of
  • phosphatidylinositol 3,4-bisphosphate
  • inositol 1,3,4-trisphosphate
  • inositol 1,4-bisphosphate
• inhibited by inositol hexakisphosphate
• involved in phosphatidylinositol signaling pathway

Structure

• belongs to the inositol-3,4-bisphosphate 4-phosphatase family
• contains 1 C2 domain

Expression

• widely expressed
• highest levels in skeletal muscle & heart

More general terms

• phosphomonoesterase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8821
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8821
• OMIM: https://mirror.omim.org/entry/607494
• UniProt: http://www.uniprot.org/uniprot/O15327.html