adenosine monophosphate [AMP] deaminase

Function

• AMP deaminase plays a critical role in energy metabolism
• catalyzes the hydrolytic deamination of AMP into IMP
• purine nucleotide cycle

Expression

• 3 isoforms are present in mammals:
• AMP deaminase 1 is the predominant form in skeletal muscle
• AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle & undifferentiated myoblasts
• AMP deaminase 3 is found in erythrocytes

More general terms

• nucleotide deaminase

More specific terms

• adenosine monophosphate deaminase-1 (AMP deaminase isoform M, myoadenylate deaminase, AMPD1)
• adenosine monophosphate deaminase-2 (AMP deaminase isoform L, AMPD2)
• adenosine monophosphate deaminase-3 (AMP deaminase isoform E, AMPD3)