adenosine monophosphate deaminase-3 (AMP deaminase isoform E, AMPD3)

Function

• AMP deaminase plays a critical role in energy metabolism
• catalyzes the hydrolytic deamination of AMP into IMP
• purine nucleotide cycle

AMP + H2O <--> IMP + NH3

Structure

• homotetramer
• belongs to the adenosine & AMP deaminases family

Alternative splicing

named isoforms=3

Expression

• found in erythrocytes

More general terms

• adenosine monophosphate [AMP] deaminase

Database

• UniProt: http://www.uniprot.org/uniprot/Q01432.html
• OMIM: https://mirror.omim.org/entry/102772
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=272