aldo-keto reductase family 7, member A2; aflatoxin B1 aldehyde reductase 2 (AKR7A2, AFAR, AFAR1, AKR7)

Introduction

phase 2 drug metabolizing enzyme

Function

• phase 2 drug metabolizing enzyme
• can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol
• may be involved in protection of liver against the toxic & carcinogenic effects of AFB1, a potent hepatocarcinogen (putative)
• probably act as a homodimer (putative)

Structure

belongs to the aldo/keto reductase 2 family

Compartment

Golgi apparatus (putative)

Expression

widely expressed

Notes

uncertain whether Met-1 or Met-30 is the initiator

More general terms

• aldo-keto reductase
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8574
• OMIM: https://mirror.omim.org/entry/603418
• UniProt: http://www.uniprot.org/uniprot/O43488.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8574