dehydrogenase/reductase SDR family member 10; 17-beta-hydroxysteroid dehydrogenase DHRS10; retinal short-chain dehydrogenase/reductase retSDR3 (DHRS10, SDR3, HSD17B14, UNQ502/PRO474)

Function

• has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity
• converts estradiol to estrone
• physiological substrate is not known
• acts on oestradiol & 5-androstene-3-beta,17-beta-diol

Structure

• homotetramer
• belongs to the short-chain dehydrogenases/reductases (SDR) family

Expression

• highly expressed in brain, placenta, liver, kidney

More general terms

• dehydrogenase/reductase SDR family (DHRS)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BPX1.html