peroxiredoxin-4; peroxiredoxin IV; Prx-IV; thioredoxin peroxidase AO372; thioredoxin-dependent peroxide reductase A0372; antioxidant enzyme AOE372; AOE37-2 (PRDX4)

Function

• probably involved in redox regulation of the cell
• regulates activation of NF-kappa-B in the cytosol by modulation of I-kappa-B-alpha phosphorylation
• homodimer or heterodimer with PRDX1; disulfide-linked, upon oxidation (putative)
• the active site is the redox-active Cys-124 oxidized to Cys-SOH
• Cys-SOH rapidly reacts with Cys-245-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation
• the enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin
• irreversibly inactivated by overoxidation of Cys-124 to Cys-SO3H upon oxidative stress

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH

Structure

• belongs to the ahpC/TSA family
• contains 1 thioredoxin domain

Compartment

• cytoplasm, secreted

More general terms

• tperoxiredoxin (PRDX)

Additional terms

• thioredoxin-1 (TRX)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10549
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10549
• OMIM: https://mirror.omim.org/entry/606506
• UniProt: http://www.uniprot.org/uniprot/Q13162.html