beta,beta-carotene 9',10'-dioxygenase; B-diox-II; beta-carotene dioxygenase 2 (BCO2, BCDO2)

Function

• asymmetrically cleaves beta-carotene at the 9',10' double bond to form beta-apo-10'-carotenal & beta-ionone
• also cleaves lycopene
• apocarotenals formed may be precursors for biosynthesis of retinoic acid

Cofactor: binds 1 Fe+2 ion per subunit (putative)

Structure

belongs to the carotenoid oxygenase family

Compartment

mitochondria

Alternative splicing

named isoforms=3

Expression

• highly expressed in retinal pigment epithelium
• also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle & prostate (at protein level)

More general terms

• dioxygenase
• mitochondrial protein

Additional terms

• beta-apo 10'carotenal
• beta-carotene
• beta-ionone

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83875
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83875
• OMIM: https://mirror.omim.org/entry/611740
• UniProt: http://www.uniprot.org/uniprot/Q9BYV7.html